Distinct single-component adjuvants steer human DC-mediated T-cell polarization via Toll-like receptor signaling toward a potent antiviral immune response - Institut Pasteur de Corée
Article Dans Une Revue Proceedings of the National Academy of Sciences of the United States of America Année : 2021

Distinct single-component adjuvants steer human DC-mediated T-cell polarization via Toll-like receptor signaling toward a potent antiviral immune response

Max Bastian

Résumé

Significance Vaccines profit from the addition of adjuvants to better and more specifically initiate, amplify, and shape immune responses. Although the number of adjuvant candidates has steadily increased, peaking in the current SARS-CoV-2 pandemic, little is known about their inherent mode of action. Using human blood immune cells, we established a multilayer method to systematically assess the adjuvants’ effects on innate and adaptive immune cells. By employing a multiplex analysis with cells from 30 different donors, we determined important patterns of adjuvant function. Moreover, we demonstrate correlates of an antiviral immune response using a Toll-like receptor 7/8 ligand adjuvant and single-stranded RNA. This knowledge about adjuvants’ distinct immune signatures supports the selection of safe and effective adjuvants for future vaccines.

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Immunologie
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Dates et versions

pasteur-03822550 , version 1 (20-10-2022)

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Laura Roßmann, Katrin Bagola, Tharshana Stephen, Anna-Lisa Gerards, Bianca Walber, et al.. Distinct single-component adjuvants steer human DC-mediated T-cell polarization via Toll-like receptor signaling toward a potent antiviral immune response. Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (39), pp.1073-1081. ⟨10.1073/pnas.2103651118⟩. ⟨pasteur-03822550⟩
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